Association of the TLR4 and NOD2 Polymorphisms with Childhood Acute Lymphoblastic Leukemia
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Original Article
P: 119-125
April 2018

Association of the TLR4 and NOD2 Polymorphisms with Childhood Acute Lymphoblastic Leukemia

Bezmialem Science 2018;6(2):119-125
1. İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye
2. İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Çocuk Onkoloji Anabilim Dalı, İstanbul, Türkiye
No information available.
No information available
Received Date: 16.01.2017
Accepted Date: 17.04.2017
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ABSTRACT

Conclusion:

The results showed that the TLR and NOD2 polymorphisms were not associated with the risk of ALL. However, these results need to be confirmed by further, larger case-control studies.

Results:

We found no significant differences between the ALL and control groups in terms of TLR4 Asp299Gly, TLR4 Thr399Ile, NOD2 Arg702Trp, NOD2 Gly908Arg, and NOD2 Leu1007fsinsC polymorphisms (p>0.05). However, we found markedly negative correlation between the C–G haplotype (rs2066844-rs2066845) and the risk of ALL (p=0.055).

Methods:

Genotype distributions of TLR and NOD2 polymorphisms were determined by real-time polymerase chain reaction in 102 ALL patients and 110 sex- and age-matched healthy individuals.

Objective:

Immune activation plays a critical role in the immune response against cancer. Although several genetic factors are established with regard to the development of acute lymphoblastic leukemia (ALL), the role of immunogenic genes in ALL pathogenesis remains elusive. Toll-like receptor (TLR) and nucleotide-binding oligomerization domain containing protein 2 (NOD2) receptors are essential in immune response. The aim of the study was to investigate the association between TLR4 Asp299Gly, TLR4 Thr399Ile, NOD2 Arg702Trp, NOD2 Gly908Arg, and NOD2 Leu1007fsinsC polymorphisms and the risk of childhood ALL.

Keywords:
Childhood ALL
NOD2
polymorphism
TLR4